Skin £799

Reports included in the skin focused package:

  • Detoxification Report

  • Nutrient Core Report

  • Histamine/ Methylation (depending on symptoms)

Detoxification Report

Detoxification is the physiological removal of toxic substances from the human body. It is mainly carried out by the liver, and to a lesser extent the small intestine, kidneys and lungs. Substances such as nutrients, food additives, pesticides, medications, air pollutants, alcohol and hormones are transformed from being fat-soluble to water-soluble, allowing them to be more easily excreted from the body. The process occurs in two major phases: Phase I primes toxic molecules for deactivation and Phase II finishes the deactivation and prepares for elimination.

Poor detoxification can cause symptoms such as headaches, muscle aches, fatigue, allergies, skin disorders, weight gain, bloating, acid reflux and heartburn, excessive sweating, chronic infections, subfertility, low libido, poor mental function and low stress tolerance.

The Detoxification test examines genes which impact Phase I reactions in the liver, including the cytochrome P450 oxidases, Phase II conjugation, including the UDP-glucuronosyltransferases (UGTs) and glutathione S-transferases (GSTs) and the Phase III antiporter gene ABCB1, which affects the transport of medicines and other substances into and out of cells. It also include genes that help to neutralise ROS - due to toxic intermediates (generated in Phase 1). The report identifies personalised nutritional support required to optimise detoxification.

Genes included:

CYP450s: CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C9, CYP2C19, CYP2D6, CYP2E1 and CYP3A4
Alcohol: ADH1B, ADH1C and ALDH2
Pesticides: PON1
ROS: SOD2, GPX1 and NQO1
Glucuronidation: UGT1A1, UGT1A6
Methylation: COMT and TPMT
Sulphonation: SULT1A1, SULT1E1 and SULT2A1
Acetylation: NAT1 and NAT2
Glutathione: GSTM1, GSTP1 and GSTT1
Antiporter: ABCB1

Nutrient Core Report

This test analyses how gene variants can affect food tolerance (and intolerance), appetite control and blood sugar balance, vitamin and mineral needs, detoxification ability, and susceptibility to inflammation and infection.

Nutrient Core will help you understand the fundamental genetic interactions with diet and lifestyle and indicate whether specific functions require further genetic testing. It includes genes that have been shown to affect:

  • food response - gluten (coeliac) and lactose intolerance

  • caffeine - sensitivity and metabolism

  • microbiome - diversity

  • vitamin need - vitamins A, B9 (folate), B12 (cobalamin), C, D and K

  • blood pressure - sodium-potassium balance & salt sensitive hypertension

  • detoxification - glutathione

  • metabolism - blood sugar control (insulin), appetite (leptin)

  • inflammation - specific (infection response) and systemic

  • circadian rhythm - early bird or night owl predisposition

Genes Included:

Food Response: HLA-DQA1, HLA-DQB1 and LCT
Caffeine: CYP1A2 and ADORA2A
Microbiome: FUT2
Vitamins: BCO1, MTHFR, FUT2, TCN2, SLC23A1, COL1A1, GC, VDR and VKORC1
Blood Pressure: ACE and AGT
Detoxification: GSTM1
Metabolism: FADS1/2, FTO, TCF7L2, PGC1A and LEPR
Inflammation: TNF and IFNG
Circadian Rhythm: CLOCK and PER1

Histamine Intolerance Report

Histamine has many functions: as a neurotransmitter, communicating messages to and from the brain and nervous system; triggering the release of stomach acid to help digestion; and it can also be released after stress, injury or allergic reaction as part of the body’s immune response.

Histamine intolerance is the body’s reaction to an imbalance between accumulated histamine and the capacity to break it down. When the body is unable to break histamine down quickly enough it becomes toxic. Symptoms of histamine toxicity may include skin irritation or breathing difficulties (mimicking an allergic reaction), digestive problems, headaches, insomnia and anxiety.

The Histamine Intolerance test analyses the genes and nutrients needed to breakdown and remove histamine, showing where disruptions occur and how to support optimal function. Diamine oxidase (DAO), which primarily breaks down histamine in the gut, can be impaired by gastrointestinal disease or ‘blockers’ such as alcohol, smoked or fermented foods, black tea, green tea and some medications such as non steroidal anti-inflammatory medications (ibuprofen or aspirin). Insufficient histamine-n-methyl- transferase (HNMT) in the nervous system and lungs can also lead to histamine overload.

Genes included:

Nervous, Immune: HNMT, MAOB and NAT2
Methylation: MTHFR
Gastro Intestinal: ALDH2, DAO and GPX1

Methylation Report

Methylation is the process of adding methyl groups, consisting of one carbon and three hydrogen atoms, to other molecules. It is involved in almost every metabolic process in the body, occurring billions of times every second in our cells and contributing to numerous crucial functions.

Imbalances in methylation - too little or too much - can increase susceptibility to chronic health conditions such as heart disease, circulatory problems, chronic fatigue, infertility, immune and autoimmune conditions, food and chemical sensitivities, and mood and psychiatric disorders, as well as cancer and premature ageing.

The Methylation test examines genes involved in five sub-cycles - folate, methionine, neurotransmitter, transsulphuration and urea. Genetic results will inform whether someone is likely to be poor or overly efficient at processing cofactors - B6, B9 (folate) and B12 (cobalamin), methionine, betaine, choline, zinc and magnesium; and inhibitors - chemicals, moulds, drugs, hormones and heavy metals and provide guidance on how to support or bypass bottlenecks or weaknesses.

Genes included:

Folate Cycle: DHFR, FOLH1, MTHFD1, MTHFR, RFC1, SHMT1 and TYMS
Methionine Cycle: AHCY, BHMT, CHDH, FUT2, MAT1A, MTR, MTRR, PEMT and TCN2
Neurotransmitter Cycle: COMT, MAOA, MAOB, MTHFR, PNMT, QDPR and VDR
Transsulphuration Cycle: CBS, CTH, GSS, MUT and SUOX
Urea Cycle: BDKRB2, NOS and SOD

All of the Lifecode Gx reports include:

  • personalised, colour coded genotype results

  • gene function and SNP impact descriptions

  • clinically relevant SNPs

  • nutrient and other epigenetic impacts

  • links to research evidence