Period / Perimenopause £799
Reports included in the period/ perimenopause focused package:
Hormones
Methyation
Histamine
Whether you are a teen struggling with period pains or you are shifting into the perimenopause and starting to experience irregularities this package is for you. Getting to know your default programming around your hormones can help gain a deeper understanding of why you are experiencing what you are experiencing and what you can do about it.
Hormones Report
Steroid hormones are a group of hormones derived from cholesterol including progesterone, oestrogen, testosterone, DHEA, and cortisol (and their derivatives). They are involved in the regulation of many physiological processes in both men and women, such as the development and function of the reproductive system, metabolism, inflammation and immune system. Steroid hormones are generally carried in the blood, bound to specific carrier proteins. Further metabolism and catabolism occurs in the liver, in other peripheral tissues, and in target tissues.
Symptoms of steroid hormone imbalance can affect men and women, and include: infertility, low libido and sex drive, low sperm count, acne, excess facial hair in women, PCOS, blood clots, mood swings, depression, substance misuse, poor memory, weight gain (belly fat for men), breast appearances in men, and hormone sensitive cancers, such as breast cancer or prostate cancer.
The Hormones test analyses genes involved in the regulation, synthesis, signalling, transport and metabolism of corticosteroids and sex steroids hormones. It looks at how gene variants affects hormones imbalance and details the nutrients and environmental factors that can influence and improve their balance. The Hormones report is recommended for men and women with hormone imbalance symptoms such as the ones listed above.
Genes included:
Steroid Hormones: AKR1C4, CYP17A1, GABRA2, HSD11B1, SRD5A2, SULT2A1
Oestrogen: COMT, CYP1A1, CYP1B1, CYP3A4, CYP19A1, ESR1, ESR2, MTHFR, NQO1
Detoxification: ABCB1, GSTM1, GSTP1, SULT1A1, SULT1E1, UGT1A1
HPA Axis: ADRB1, ADRB2, FKBP5, MTNR1B, OPRM1, TCF7L2
HPG Axis: ESR1, ESR2, FAAH
Methylation Report
Methylation is the process of adding methyl groups, consisting of one carbon and three hydrogen atoms, to other molecules. It is involved in almost every metabolic process in the body, occurring billions of times every second in our cells and contributing to numerous crucial functions.
Imbalances in methylation - too little or too much - can increase susceptibility to chronic health conditions such as heart disease, circulatory problems, chronic fatigue, infertility, immune and autoimmune conditions, food and chemical sensitivities, and mood and psychiatric disorders, as well as cancer and premature ageing.
The Methylation test examines genes involved in five sub-cycles - folate, methionine, neurotransmitter, transsulphuration and urea. Genetic results will inform whether someone is likely to be poor or overly efficient at processing cofactors - B6, B9 (folate) and B12 (cobalamin), methionine, betaine, choline, zinc and magnesium; and inhibitors - chemicals, moulds, drugs, hormones and heavy metals and provide guidance on how to support or bypass bottlenecks or weaknesses.
Genes included:
Folate Cycle: DHFR, FOLH1, MTHFD1, MTHFR, RFC1, SHMT1 and TYMS
Methionine Cycle: AHCY, BHMT, CHDH, FUT2, MAT1A, MTR, MTRR, PEMT and TCN2
Neurotransmitter Cycle: COMT, MAOA, MAOB, MTHFR, PNMT, QDPR and VDR
Transsulphuration Cycle: CBS, CTH, GSS, MUT and SUOX
Urea Cycle: BDKRB2, NOS and SOD
Histamine Intolerance Report
Histamine has many functions: as a neurotransmitter, communicating messages to and from the brain and nervous system; triggering the release of stomach acid to help digestion; and it can also be released after stress, injury or allergic reaction as part of the body’s immune response.
Histamine intolerance is the body’s reaction to an imbalance between accumulated histamine and the capacity to break it down. When the body is unable to break histamine down quickly enough it becomes toxic. Symptoms of histamine toxicity may include skin irritation or breathing difficulties (mimicking an allergic reaction), digestive problems, headaches, insomnia and anxiety.
The Histamine Intolerance test analyses the genes and nutrients needed to breakdown and remove histamine, showing where disruptions occur and how to support optimal function. Diamine oxidase (DAO), which primarily breaks down histamine in the gut, can be impaired by gastrointestinal disease or ‘blockers’ such as alcohol, smoked or fermented foods, black tea, green tea and some medications such as non steroidal anti-inflammatory medications (ibuprofen or aspirin). Insufficient histamine-n-methyl- transferase (HNMT) in the nervous system and lungs can also lead to histamine overload.
Genes included:
Nervous, Immune: HNMT, MAOB and NAT2
Methylation: MTHFR
Gastro Intestinal: ALDH2, DAO and GPX1
All of the Lifecode Gx reports include:
personalised, colour coded genotype results
gene function and SNP impact descriptions
clinically relevant SNPs
nutrient and other epigenetic impacts
links to research evidence